Suppressor
نویسندگان
چکیده
منابع مشابه
DNA methylation of tumor suppressor genes in hepatocellular carcinoma
The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
متن کاملThe murine dilute suppressor gene encodes a cell autonomous suppressor.
The murine dilute suppressor gene (dsu) suppresses the coat-color phenotype of three pigment mutations, dilute (d), ashen (ash) and leaden (ln), that each produce adendritic melanocytes. Suppression is due to the ability of dsu to partially restore (ash and ln), or almost completely restore (d), normal melanocyte morphology. While the ash and ln gene products have yet to be identified, the d ge...
متن کاملThe RASSF1A tumor suppressor.
RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by inappropriate promoter methylation. This epigen...
متن کاملAnti - Self - Suppressor Cells
The mechanisms involved in the induction and maintenance of self-tolerance remain unclear. The traditional point of view is that self-reactive cells are eliminated by clonal deletion (1) and many specific mechanisms, such as receptor blockade (2), have been proposed for achieving this. A more recent, contrasting point of view (3, 4) is that self-tolerance is achieved through regulatory procedur...
متن کاملTumor suppressor genes.
Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Allelic chromosomal losses as well as mutations of tumor suppressor genes are common genetic events in the development and/or progression of both hereditary and non-hereditary tumors. Recent studies have shown a direct correlation between malignancy and in...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1966
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.6.72